Desperate Living marked a painful rupture in John Waters's original acting ensemble. David Lochary, a key performer in Waters's earlier films, did not appear in the 1977 production because of his addiction to PCP. Waters later described the decision with extraordinary bluntness: 'The reason that David wasn't in Desperate Living is because of PCP. That's all that's to it. I know that's why he wasn't in the film, and he knows it, too.' The absence was especially significant because the film was already breaking with Waters tradition: Divine, the director's most famous collaborator, had to withdraw after committing to Women Behind Bars, and Lochary became another conspicuous missing member of the old repertory company. Only weeks after Desperate Living was released, Lochary died after injuring himself while under the influence of PCP. His death transformed what might have looked like a casting and professional-discipline issue into one of the darkest tragedies surrounding Waters's early films, closing the story of one of the director's most volatile and distinctive collaborators.
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