Bug’s sinister scientific setting was assembled through an unusually recognizable piece of television recycling. The interior set representing Professor James Parmiter’s house had previously been used as the Brady family home for the sitcom The Brady Bunch, which had been canceled before Bug began shooting. The cheerful suburban television environment was therefore repurposed for a much darker story involving a widowed scientist, an insect that kills his wife, pressure chambers, secret breeding experiments, and intelligent flying cockroaches. Production also combined specially designed mechanical or model insects with real cockroaches bred under the supervision of a University of California, Riverside entomologist. Exterior scenes were filmed in Riverside, California, where then-mayor Ben H. Lewis—himself a former actor—made a cameo as himself. The result was a particularly strange collision of television familiarity and low-budget horror mechanics: audiences could recognize the domestic architecture while watching it transformed into the secluded laboratory of a man losing control of his scientific obsession.
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